The league leaders travel to Sevilla to face a Betis side on the rise and currently in ninth place on the table. There should be plenty of goals and drama on Sunday night with the hosts' La Liga matches averaging more goals (3.63) this season than any other side, and the Andalusians boast the third-best attack but the fourth-worst defence.
Betis manager Quique Setien could face Barcelona with a 4-3-3 formation, deploying Joaquín, Sergio León and former Barca man Tello as a front three to attempt to beat Ter Stegen.
On the other hand, Ernesto Valverde may have to make do without Paulinho, who sustained an injury against Espanyol and is a doubt, while Ousmane Dembele is facing another spell on the sidelines, but Samuel Umtiti is pressing for a return from an injury which has kept him out for nearly two months.
Philippe Coutinho is stepping up his fitness but will have to wait for his Barcelona debut, meaning a 4-4-2 formation is likely, led by Luis Suarez and Lionel Messi.
Potential lineups:
Real Betis: Adán; Francis, Mandi, Feddal, Durmisi; Fabián, Javi García, Guardado; Joaquín, Sergio León and Tello.
Barcelona: Ter Stegen; Sergi Roberto, Vermaelen, Piqué, Jordi Alba; Paulinho, Sergio Busquets, Rakitic, André Gomes; Luis Suárez and Lionel Messi.