Should Jesus feature in Sunday's game, it will be only his second appearance in a Manchester derby after he played in the 0-0 draw between the two side back in April.
The importance of the game is not lost on the Brazilian though, who believes there are similarities between the derby and the bitter rivalry between Brazil and Argentina.
'A little bit, yes,' Jesus told 'Sport360' when asked if the two rivalries were similar.
'I think Brazil-Argentina is a bigger rivalry because we're talking about two national teams, two countries. But it's not that distant, it's similar, it's a Classico.
'It's going to be a good match, a big match, between big players from big clubs.
'We'll try to win because it's very important. It's also a head-to-head match with our positions in the table. So there's the size of the match, but we have to be clear that we're going there to try to win.
'I don't believe United will play defensively because just like us, they need the result. If they play like they did against Arsenal [when they attacked], that will make it an open game and that will suit us.'
City go into the game knowing that a win could give them what many pundits are calling an almost unassailable lead at the top of the Premier League, despite the season being yet to reach the halfway stage.
Meanwhile, Jesus has added motivation to fire City to glory as he looks to keep adding to the collection of tattoos he has celebrating various trophy wins.
However, a Premier League might not be enough of an achievement for the starlet to merit being recreated in ink.
'Yes, I would add more (tatoos),' he admitted. 'A Premier League tattoo, I would have to think about it.
'But if we win the World Cup I would definitely do a tattoo. And if I ever win the Champions League I would also do one.'
Who will be on the winning side tomorrow? Join us for live coverage of the game to find out!