City look to extend their impressive unbeaten run in the FA Cup against a Burnley side backed by some 7,600 travelling fans.
Burnley are without midfielder Scott Arfield after he sustained a minor hamstring strain in the home defeat to Liverpool on New Year's Day.
David Silva and Sergio Aguero feature for Manchester City, with Zinchenko making a rare start at left-back.
City: Bravo, Danilo, Stones, Otamendi, Zinchenko, Gundogan, Fernandinho, Silva, Sterling, Sane, Aguero
Burnley: Pope, Lowton, Long, Mee, Taylor, Gudmundsson, Cork, Westwood, Barnes, Hendrick, Vokes