Arsenal and Stoke have developed somewhat of a bitter rivalry over recent years which intensified after a tackle from Ryan Shawcross broke Aaron Ramsey's leg in 2010.
However, Wenger believes his new-signing Sead Kolasinac has the credentials to deal with the traditionally physical Stoke side when they travel to the Bet365 Stadium on Saturday.
"He has started well," Wenger said of the Bosnian international.
"Maybe he is the strongest, he is naturally strong. He uses quite well the strength of his body without violence and when he intervenes it doesn't look to be a foul, he just uses his body strength.
"It is an important quality to help adapt to the Premier League.
"He has the capacity to repeat runs and we noticed when we watched him play that he is quite dangerous in the final third.
"He already has some assists since he came here so overall maybe he is not a glamorous dribbler but the quality of his runs are very efficient.
"The determined attitude gets to the crowd and that gives a swing to the team, you can see that with him and when he intervenes he provokes happiness."
Most Arsenal fans have already warmed to Kolasinac, following his late equaliser in the Community Shield win against Chelsea earlier this month. He then followed that up with an assist on his league debut, setting up Danny Welbeck to score against Leicester.
Wenger said it was a "no-brainer" to sign the defender on a free transfer after his contract ran out at Schalke. He also believes it offsets the club-record pee which Arsenal paid for Alexandre Lacazette.
"I think it was a good opportunity in Germany because we knew he was at the end of his contract," he said.
"Watching him, I thought he had the quality. I met him and he had a good spirit and a good attitude so basically overall it was a no-brainer for us.
"It is a nice bargain because it allows you to divide your buy by two. When you buy two players, the price of one you buy you can divide by two. One player for £50m is two for £25m.
"You might find it more and more, I have said it many times, that more and more players will go to the end of their contract because the transfer is too high, the inflation is too high and the agents will be demanding and clubs will not be in a position to extend contracts."