The Spanish manager is looking to put his rotation system in place. The regulars need a rest and it looks like there will be several new faces on the pitch at the Camp Nou.
Summer signing Nelson Semedo will start at right-back, while Lucas Digne will be on the left. Gerard Pique and Javier Mascherano will be in central defence.
There will also be a few changes in midfield. Ivan Rakitic will take Paulinho's place, and Sergio Busquets and Andres Iniesta could be alongside the Croatian playmaker.
Leading the line, Leo Messi and Luis Suarez are unquestionable. The man to complete the attacking trio could be Gerard Deulofeu.
Here is the potential starting lineup to face Malaga: Ter Stegen; Semedo, Pique, Mascherano, Digne; Sergio Busquets, Rakitic, Iniesta; Deulofeu, Messi, Luis Suarez.