The Spanish tactician has made seven changes to the side that beat Leicester 2-0 on Saturday.
Only Ederson, Kyle Walker, Kevin De Bruyne and Raheem Sterling keep their places in the starting XI, with Sergio Aguero replacing Gabriel Jesus up front and Nicolas Otamendi returning from domestic suspension.
City XI | Ederson, Walker, Mangala, Otamendi, Danilo, Gundogan, Yaya Toure, De Bruyne, Bernardo, Sterling, Aguero (C)
— Manchester City (@ManCity) November 21, 2017
Subs | Bravo, Foden, Delph, Silva, Fernandinho, Diaz, G Jesus#cityvfey #mancity pic.twitter.com/XYb7gg1pfD
Feyenoord have also made a number of changes to their side that drew 1-1 with VVV Venlo on the weekend.
Kevin Diks, Renato Tapia, Sofyan Amrabat and Jean Paul-Boetius all come in, while former Liverpool goalkeeper Brad Jones starts between the sticks.
LINE-UP FEYENOORD #mcifey #UCL pic.twitter.com/qevtst4WO5
— Feyenoord Rotterdam (@Feyenoord) November 21, 2017