Lyon:
The hosts will have a near full-strength side, with only Pape Cheikh unavailable for them.
Ferland Mendy missed the reverse fixture two weeks ago but could be in line for a start this evening.
Everton:
Interim manager David Unsworth has confirmed that star trio Wayne Rooney, Leighton Baines and Phil Jagielka will all be rested for the trip to France.
Academy defender Morgan Feeney will travel with the squad, but won't start.
Meanwhile, Michael Keane (infection), Seamus Coleman (leg), Ramiro Funes Mori, Yannick Bolasie (both knee) and Ross Barkley (hamstring) all remain sidelined.
Recent form:
Possible lineups:
Lyon: Lopes; Tete, Marcelo, Diakhaby, Marcal; Aouar, Tousart, Ferri; Traore, Fekir, Depay
Everton: Pickford; Kenny, Williams, Jagielka, Holgate; Schneiderlin, Gueye; Lookman, Sigurdsson, Mirallas; Niasse