Madrid are in desperate need of a convincing three points after the shock home loss left 'Los Blancos' in eighth place in the La Liga standings, seven points behind leaders Barcelona.
Alaves:
Zinedine Zidane could come up against his son, Enzo Zidane, for the first time, with the midfielder expected to play a part at the Mendizorroza Stadium.
Forward Bojan Krkic will miss the tie after sustaining a thigh injury against Villarreal last weekend.
Real Madrid:
Zidane could choose to rest some of his star players with the midweek Champions League clash against Borussia Dortmund in mind.
Cristiano Ronaldo returned to action against Betis and is in line to make his second start in four days.
Midfield maestro Toni Kroos missed training on Friday and will take no part due to an injury, while Luka Modric could be given a break handing a rare opportunity to Dani Ceballos in the starting XI.
Theo Hernandez, Karim Benzema, Mateo Kovacic and Marcelo are also all out injured.
Possible lineups:
Alaves: Pacheco, Vigaray, Alexis, Maripan, Galilea, Romero, Zidane, Medran, Santos, Bojan, Munir.
Real Madrid: Navas, Carvajal, Varane, Ramos, Nacho, Ceballos, Casemiro, Isco, Bale, Ronaldo, Asensio.